Agata Sowińska

email: agata.sowinska(at)p.lodz.pl
phone: +48 42 631 3198
office: Room 125, Faculty of Chemistry,
Zeromskiego 116

Research Interests:

  • computational chemistry
  • molecular modeling
  • ligand-receptor interactions
  • docking
  • biochemistry

Education:

2019 Ph.D. in Chemistry, Faculty of Biotechnology and Food Science, Lodz University of Technology, Poland: Synthesis, biological studies and molecular modeling of ligand-receptor interactions of analogues of selected lysophospholipids, Supervisor: Prof. Maria Koziołkiewicz

Professional Experience:

2019-present: Assistant Professor, Faculty of Chemistry, Lodz University of Technology

Selected Publications:

  1. M. Rostkowski, H. Schurner, A. Sowińska, L. Vasquez, M. Przydacz, M. Elsner, A. Dybala-Defratyka, Isotope Effects on the Vaporization of Organic Compounds from an Aqueous Solution – Insight from Experiment and Computations, J. Phys. Chem. B, 125 (2021) 13868, DOI: 10.1021/acs.jpcb.1c05574
  2. A. Sowińska, L. Vasquez, S. Żaczek, R. N. Manna, I. Tuñón, A. Dybala-Defratyka, Seeking the Source of Catalytic Efficiency of Lindane Dehydrochlorinase, LinA, J. Phys. Chem. B 124 (2020) 10353, DOI: 10.1021/acs.jpcb.0c08976
  3. Drzazga, A., Sowińska, A., Krzemińska, A., Okruszek, A., Paneth, P., Koziołkiewicz, M., Gendaszewska-Darmach, E. 2-Methoxy-lysophosphatidylcholine analogues are GPR119 ligands and activate insulin secretion from <beta>TC-3 pancreatic cells: evaluation of structure-dependent biological activity, Biochim Biophys Acta Mol Cell Biol Lipids, 2018, 1863, 91, DOI: 10.1016/j.bbalip.2017.10.004
  4. Drzazga, A., Sowińska, A., Krzemińska, A., Rytczak, P., Koziołkiewicz, M., Gendaszewska-Darmach, E.,  Lysophosphatidylcholine elicits intracellular calcium signaling in a GPR55-dependent manner, Biochem Biophys Res Commun, 2017, 489, 242, DOI: 10.1016/j.bbrc.2017.05.145
  5. Sowińska, A., Rytczak, P., Gendaszewska-Darmach, E., Drzazga, A., Koziołkiewicz, M., Okruszek, A., The chemical synthesis and preliminary biological studies of phosphodiester and phosphorothioate analogues of 2-methoxy-lysophosphatidylethanolamine, Bioorg Med Chem Lett, 2016, 26, 3725, DOI: 10.1016/j.bmcl.2016.05.075
  6. Drzazga, A., Sowińska, A., Koziołkiewicz, M., Lysophosphatidylcholine and lysophosphatidylinositol – novel promissing targets in therapy; Acta Pol Pharm, 2014, 71, 887