Piotr Paneth

email: piotr.paneth(at)p.lodz.pl
www: paneth.p.lodz.pl
phone: +48 42 631 3199

office: Room 114, Faculty of Chemistry, Zeromskiego 116

Research Interests:

  • theory of isotope effects
  • application isotope effects to studies of mechanisms of biochemical reactions and their chemical models
  • rational drug design
  • development of methodology of measuring isotope effects
  • isotopic food authentication
  • use of isotopic fractionation in environmental studies
  • theoretical modeling of reactions mechanisms

Education:

1996 Professor titular: President of the Republic of Poland
1989 D.Sc. (habilitation): Chemistry, Department of Chemistry, Technical University of Lodz, Poland Isotope effects on kinetically complex reactions
1984 Ph.D. (with honors): Chemistry, Department of Chemistry, Technical University of Lodz, Poland Oxygen and sulfur kinetic isotope effects on thermal isomerization of  bis(5,5-dimethyl-1,3,2,-dioxaphosphorinanyl); supervisor: prof. W Reimschüssel

Professional Experience:

2007 Visiting Professor, FIFC, University of Kyoto (1.5 month)

2006-2007 Visiting Professor, LAIEM CNRS UMR 6006 laboratory, Nantes, France (3 months)

2003 Visiting Professor, Department of Chemistry, Emerson Center, Emory University, Atlanta, GA (3 months)

2000-2001 Visiting Professor, Department of Chemistry, University of Minnesota, Minneapolis, MN, USA (9 months)

1998-1999 Visiting Professor, Department of Chemistry, University of Uppsala, Uppsala, Sweden (4 months)

1995 Visiting Professor, Department of Biochemistry, University of Nebraska, Lincoln, NE, USA (3 months)

1989-1992 Post-doctoral, Department of Biochemistry, University of Nebraska, Lincoln, NE, USA; with Marion H. O’Leary, Professor and Head 1984-1986 Senior post-doctoral, Department of Chemistry, University of Wisconsin, Madison, WI, USA; with Marion H. O’Leary, Professor

Research grants/fellowships:

National Science Center (Maestro, 2012-2017), Binding isotope effects as new, unique tool for studies of receptor-ligand interactions

Polish-Swiss Joint Research Project (2011-2015), Novel stable isotope-based approaches for assessing the biodegradation of soil and groundwater contaminants

FP7 Maria Curie Action (ITN, 2010-2014), CSI: Environment—Isotope forensics meets biogeochemistry – linking sources and sinks of organic contaminants by compound specific isotope investigation

Representative publications:

  1. K. Świderek, P. Paneth, Binding Isotope Effects, Chem. Rev. 113 20137851
  2. K. Świderek, P. Paneth, Extending Limits of Chlorine Kinetic Isotope Effects,  J. Org. Chem. 77 2012 5120
  3. A. Dybala-Defratyka, P. Adamczyk, P. Paneth, DFT Study of Trichloroethene Reaction with Permanganate in Aqueous Solution, Env. Sci. Technol. 45 2011 3006
  4. M. Wolfsberg, A. Van Hook, P. Paneth, Isotope Effects in the Chemical, Geological and Bio Sciences, Springer, London, 2010
  5. X. Li, L.W. Chung, P. Paneth and K. Morokuma, DFT and ONIOM(DFT:MM) Studies on Co-C Bond Cleavage and Hydrogen Transfer in B12-Dependent Methylmalonyl-CoA Mutase. Stepwise or Concerted Mechanism?  J. Am. Chem. Soc. 131 2009 5115
  6. K. Świderek, A. Panczakiewicz, A. Bujacz, G. Bujacz, P. Paneth, Modeling of isotope effects on binding oxamate to lactic dehydrogenase,  J. Phys Chem. B 113 2009 12782
  7. A. Dybala-Defratyka, L. Szatkowski, R. Kaminski, M. Wujec, A. Siwek, P. Paneth, Kinetic isotope effects on dehalogenation at an aromatic carbon,  Environ. Sci. Technol. 42 2008 7744
  8. A. Dybala-Defratyka, P. Paneth, R. Banerjee, D.G. Truhlar, Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase, Proc. Natl. Acad. Sci. USA, 104 2007 10779
  9. P. Paneth, Chlorine Kinetic Isotope Effects on Enzymatic Dehalogenations, Acc. Chem. Res. 36 2003 120
  10. V. Anisimov, P. Paneth, ISOEFF98. A Program for Studies of Isotope Effects Using Hessian Modifications,  J. Mathem. Chem. 26 1999 75